1: 1,2,4,5-tetrafluoro-3-bromobenzene With magnesium in tetrahydrofuran T=20°C; 1 h; 2: With copper(I) bromide in tetrahydrofuran; 1,4-dioxane T=20°C; 3: 1,4-dibromo-2,3,5,6-tetrafluorobenzene in tetrahydrofuran; 1,4-dioxane; toluene T=80°C; 48 h; Further stages.;

1: tetrahydrofuran / Ambient temperature 2: methanolic RuCl3 / Irradiation View Scheme

1: tetrahydrofuran / Ambient temperature 2: methanolic RuCl3 / Irradiation View Scheme

ruthenium trichloride Irradiation;

1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; copper(I) thiophene-2-carboxylate 1.) NMP, room temperature, 96 h, 2.) ether, THF, 0 deg C, 1 h.; Yields of byproduct given;