1,3-二溴-5-硝基苯合成路线 （共 57 条）
参考文献
Bunnett et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 5755,5761
反应条件
potassium hydroxide; tetrabutylammomium bromide in N,N,N',N'-tetramethyl-urea T=20°C; 24 h;
参考文献
LOCUS PHARMACEUTICALS, INC.
Patent: WO2008/8059 A1, 2008 ;
Location in patent: Page/Page column 96 ;
反应条件
hydrogenchloride; tin T=90°C; 7 h;
参考文献
Onitsuka, Kiyotaka; Fujimoto, Masanori; Kitajima, Hotaka; Ohshiro, Nobuaki; Takei, Fumie; Takahashi, Shigetoshi
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6433 - 6446
参考文献
Blansksma
Recueil des Travaux Chimiques des Pays-Bas, 1909 , vol. 28, p. 111
Chem. Zentralbl., 1908 , vol. 79, # II p. 1826
反应条件
1: tin; hydrochloric acid 2: durch Ueberfuehrung in das Diazoniumperbromid und dessen Zersetzung mit Alkohol View Scheme
参考文献
Baliah, V.; Jeyanthy, J. Judith Diana
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1989 , vol. 28, # 6 p. 472 - 476
反应条件
potassium hydroxide; oxygen; tetrabutylammomium bromide in N,N,N',N'-tetramethyl-urea T=20°C; 7 h;
参考文献
US2006/270686 A1, ;
Page/Page column 24 ;
反应条件
1: HNO3+H2SO4 2: alkaline solution View Scheme
参考文献
Blanksma
Recueil des Travaux Chimiques des Pays-Bas, 1908 , vol. 27, p. 36
反应条件
1: iron; diluted sulfuric acid 2: alcoholic sulfuric acid; sodium nitrite 3: beim Nitrieren View Scheme
参考文献
Holleman
Recueil des Travaux Chimiques des Pays-Bas, 1906 , vol. 25, p. 202
Recueil des Travaux Chimiques des Pays-Bas, 1908 , vol. 27, p. 151,159
反应条件
1: iron; diluted sulfuric acid 2: alcoholic sulfuric acid; sodium nitrite View Scheme
参考文献
Holleman
Recueil des Travaux Chimiques des Pays-Bas, 1906 , vol. 25, p. 202
Recueil des Travaux Chimiques des Pays-Bas, 1908 , vol. 27, p. 151,159
反应条件
1.1: 89 percent / SnCl2*2H2O / ethanol; tetrahydrofuran / 20 h / 20 °C 2.1: H2SO4; NaNO2 / 2 h / 0 °C 2.2: 70 percent / KI / 0.25 h / 80 °C 3.1: 91 percent / CuI; Et3N / (Ph3P)2PdCl2 / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 23 p. 8750 - 8766
