5-氯-咪唑并[1,2-a]吡啶合成路线 （共 9 条）
反应条件
1: chloroacetaldehyde dimethyl acetal With toluene-4-sulfonic acid in ethanol; water T=20 - 65°C; 2: With sodium hydrogencarbonate in ethanol; water T=20°C; pH=7; 3: 6-amino 2-chloro pyridine in ethanol; water 3 h; Reflux;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 80 ;
WO 2009/135842 A1
反应条件
1: in ethanol; water 5 h; Reflux; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
WO2013/64984 A1, ;
Page/Page column 78-79 ;
WO 2013/064984 A1
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 6 p. 3125 - 3140
反应条件
sodium hydroxide; sodium chloride; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in acetic acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235731 B1, 2001 ;
反应条件
titanium tetrachloride in dichloromethane T=20°C; 3 h;
参考文献
Ikemoto, Tomomi; Kawamoto, Tetsuji; Wada, Hiroki; Ishida, Toru; Ito, Tatsuya; Isogami, Yasushi; Miyano, Yoshiko; Mizuno, Yukio; Tomimatsu, Kiminori; Hamamura, Kazumasa; Takatani, Muneo; Wakimasu, Mitsuhiro
Tetrahedron, 2002 , vol. 58, # 3 p. 489 - 493
反应条件
acetic acid T=85°C; Duff reaction; 5 h;
参考文献
Ikemoto, Tomomi; Kawamoto, Tetsuji; Wada, Hiroki; Ishida, Toru; Ito, Tatsuya; Isogami, Yasushi; Miyano, Yoshiko; Mizuno, Yukio; Tomimatsu, Kiminori; Hamamura, Kazumasa; Takatani, Muneo; Wakimasu, Mitsuhiro
Tetrahedron, 2002 , vol. 58, # 3 p. 489 - 493
反应条件
trichlorophosphate T=90 - 100°C; Vislmeier reaction; 3 h;
参考文献
Ikemoto, Tomomi; Kawamoto, Tetsuji; Wada, Hiroki; Ishida, Toru; Ito, Tatsuya; Isogami, Yasushi; Miyano, Yoshiko; Mizuno, Yukio; Tomimatsu, Kiminori; Hamamura, Kazumasa; Takatani, Muneo; Wakimasu, Mitsuhiro
Tetrahedron, 2002 , vol. 58, # 3 p. 489 - 493
反应条件
hydrogenchloride; sodium hydroxide; sodium methylate in N-methyl-acetamide; ethyl acetate
参考文献
Pfizer Inc.
Patent: US4097598 A1, 1978 ;
