3-羟基-5-甲基-2-苯并呋喃-1(3H)-酮合成路线 （共 8 条）
反应条件
1: 83 percent / H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr
2: 1.) NBS, benzoyl peroxide, 2.) H2O / 1.) CCl4, reflux, 1 h, 2.) reflux
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
1: NBS, benzoyl peroxide / CCl4 / 3 h / Heating
2: 1 h / 180 °C / 10 Torr
3: 83 percent / H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr
4: 1.) NBS, benzoyl peroxide, 2.) H2O / 1.) CCl4, reflux, 1 h, 2.) reflux
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
1: 1 h / 180 °C / 10 Torr
2: 83 percent / H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr
3: 1.) NBS, benzoyl peroxide, 2.) H2O / 1.) CCl4, reflux, 1 h, 2.) reflux
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
hydrogenchloride; acetic acid in water
24 h; RefluxInert atmosphere;
参考文献
Yang, Guoqiang; Zhang, Wanbin
Organic Letters, 2012 , vol. 14, # 1 p. 268 - 271
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: -50 - 20 °C / Inert atmosphere
2.1: hydrogenchloride; acetic acid / water / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Yang, Guoqiang; Zhang, Wanbin
Organic Letters, 2012 , vol. 14, # 1 p. 268 - 271
反应条件
1.1: triethylamine / toluene / 24 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: -50 - 20 °C / Inert atmosphere
3.1: hydrogenchloride; acetic acid / water / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Yang, Guoqiang; Zhang, Wanbin
Organic Letters, 2012 , vol. 14, # 1 p. 268 - 271
反应条件
potassium carbonate in methanol
参考文献
Meyer,A. et al.
Chemische Berichte, 1977 , vol. 110, p. 1403 - 1420
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid; water
1.) CCl4, reflux, 1 h, 2.) reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
