2-氧代-1,2-二氢喹啉-6-甲腈合成路线 （共 4 条）
反应条件
in 1-methyl-pyrrolidin-2-one
T=20 - 202°C; 6 h; Heating / reflux;
参考文献
Hohlweg, Rolf; Dorwald, Florencio Zaragoza; Stephensen, Henrik; Pettersson, Ingrid; Peschke, Bernd
Patent: US2003/236259 A1, 2003 ;
Location in patent: Page 54 ;
US 20030236259 A1
反应条件
1: in 1-methyl-pyrrolidin-2-one
T=202°C; 7 h;
2: With hydrogenchloride; iron(III) chloride
T=20°C; 72 h;
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
反应条件
1.1: sulfuric acid / 1.5 h / 20 °C
2.1: 1-methyl-pyrrolidin-2-one / 7 h / 202 °C
2.2: 91 percent / FeCl3*6H2O; aq. HCl / 72 h / 20 °C
View Scheme
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
反应条件
trichlorophosphate
T=110°C; 2 h;
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Peschke, Bernd; Rimvall, Karin
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 306 - 311
