(S)-(+)-2-(甲氧基甲基)吡唑烷合成路线 （共 24 条）
反应条件
1: L-prolinol With sodium hydride in dichloromethane T=0°C; 1 h; 2: methyl iodide in dichloromethane T=0°C; 1 h;
参考文献
US6900238 B1, ;
Page/Page column 35 ;
反应条件
hydrogen; nickel in methanol T=20 - 40°C; P=2625.2 - 2850.2 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
hydrogen; nickel in methanol T=20 - 40°C; P=2625.2 - 2850.2 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
hydrogen; nickel in methanol T=20 - 40°C; P=2625.2 - 2850.2 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
hydrogen; nickel in methanol T=20 - 40°C; P=2625.2 - 2850.2 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
hydrogen; nickel in methanol T=20 - 40°C; P=2625.2 - 2850.2 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6704 - 6715
反应条件
1.1: 85 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / -78 °C 2.2: 77 percent / tetrahydrofuran / 20 h / -78 - 20 °C 3.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6704 - 6715
反应条件
potassium hydroxide T=70°C;
参考文献
Synthetic Communications, , vol. 12, # 9 p. 657 - 664
反应条件
boron trifluoride diethyl etherate; water 1.) benzene, RT, 24 h, 2.) benzene, RT, 20 h; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 113, # 13 p. 4931 - 4936
