(S)-(+)-2-(甲氧基甲基)吡唑烷合成路线 （共 24 条）
反应条件
1.1: NaH / tetrahydrofuran / -78 °C 1.2: 77 percent / tetrahydrofuran / 20 h / -78 - 20 °C 2.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6704 - 6715
反应条件
1: NaH / tetrahydrofuran / -60 - 20 °C 2: 10.56 g / aq. KOH / 5 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 9, # 12 p. 2845 - 2853
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / Heating 2: tetrahydrofuran / 2 h / 0 °C 3: NaH / tetrahydrofuran / -60 - 20 °C 4: 10.56 g / aq. KOH / 5 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 9, # 12 p. 2845 - 2853
反应条件
1: CB / diethyl ether / 12 h / 0 deg C to r. t. 2: H2 / Raney-Ni / methanol / 24 h / 20 - 40 °C / 2625.2 - 2850.2 Torr View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
1: CB / diethyl ether / 12 h / 0 deg C to r. t. 2: H2 / Raney-Ni / methanol / 24 h / 20 - 40 °C / 2625.2 - 2850.2 Torr View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
1: CB / diethyl ether / 12 h / 0 deg C to r. t. 2: H2 / Raney-Ni / methanol / 24 h / 20 - 40 °C / 2625.2 - 2850.2 Torr View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
1: CB / diethyl ether / 12 h / 0 deg C to r. t. 2: H2 / Raney-Ni / methanol / 24 h / 20 - 40 °C / 2625.2 - 2850.2 Torr View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
1: CB / diethyl ether / 12 h / 0 deg C to r. t. 2: H2 / Raney-Ni / methanol / 24 h / 20 - 40 °C / 2625.2 - 2850.2 Torr View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 5 p. 368 - 369
反应条件
1: With borane-THF in tetrahydrofuran Reduction; 5 h; Heating; 2: With methanol T=20°C; methanolysis; 15 h;
参考文献
Journal of the Indian Chemical Society, , vol. 76, # 11-12 p. 561 - 564
反应条件
1: 78 percent / NaIO4, RuO2 / H2O; ethyl acetate / 0.5 h / 0 °C 2: 1.) trifluoroacetic acid (TFA), 2.) 2 M aq. NaOH / 1.) reflux, 48 h, 2.) 90 deg C, 1 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 1, # 12 p. 877 - 880
