4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile 1.) 0 deg C, 2.) room temperature, 4 h;

1: 86 percent / LiAlH4 / diethyl ether / 1.) 1 h, 0 deg C, 2.) 4 h, room temperature 2: 91 percent / DMAP, Et3N / acetonitrile / 1.) 0 deg C, 2.) room temperature, 4 h View Scheme

in tetrahydrofuran 24 h; pig pancreatic lipase (PPL); Yields of byproduct given;

water T=25°C; pig pancreatic lipase(PPL) in 0.1 M phosphate buffer, pH 7.0 , kinetic constants: α=3.60, E1=0.04, E2=0.15; Kinetics;