反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 71.67 h / 20 - 100 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / 19 h / Inert atmosphere
2.2: 35 h
View Scheme
参考文献
EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun
Patent: WO2012/142513 A1, 2012 ;
WO 2012/142513 A1