4-氯-2,3-二甲基喹啉合成路线 （共 11 条）
反应条件
nickel in ethanol
T=25°C; 6 h;
参考文献
Korodi, Ferenc; Jeko, Jozsef; Szabo, Zoltan
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1275 - 1281
反应条件
thionyl chloride; N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: p-TsOH*H2O / toluene / Heating
2: 2.39 g / diphenyl ether / 1 h / 250 °C
3: 3.23 g / thionyl chloride; DMF / 1 h / 80 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 2.39 g / diphenyl ether / 1 h / 250 °C
2: 3.23 g / thionyl chloride; DMF / 1 h / 80 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: p-TsOH*H2O / toluene / Heating
2: 2.39 g / diphenyl ether / 1 h / 250 °C
3: 3.23 g / thionyl chloride; DMF / 1 h / 80 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 40 percent / 3 h / Heating
2: 99 percent / aq. NaOH / acetone / 1 h / Heating
3: 35 percent / POCl3 / 3 h / 85 °C
4: 1.) K2CO3 / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 25 deg C, 30 min
5: 68 percent / Ra Ni / ethanol / 6 h / 25 °C
View Scheme
参考文献
Korodi, Ferenc; Jeko, Jozsef; Szabo, Zoltan
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1275 - 1281
反应条件
1: 35 percent / POCl3 / 3 h / 85 °C
2: 1.) K2CO3 / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 25 deg C, 30 min
3: 68 percent / Ra Ni / ethanol / 6 h / 25 °C
View Scheme
参考文献
Korodi, Ferenc; Jeko, Jozsef; Szabo, Zoltan
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1275 - 1281
反应条件
1: 99 percent / aq. NaOH / acetone / 1 h / Heating
2: 35 percent / POCl3 / 3 h / 85 °C
3: 1.) K2CO3 / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 25 deg C, 30 min
4: 68 percent / Ra Ni / ethanol / 6 h / 25 °C
View Scheme
参考文献
Korodi, Ferenc; Jeko, Jozsef; Szabo, Zoltan
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1275 - 1281
反应条件
1: 1.) K2CO3 / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 25 deg C, 30 min
2: 68 percent / Ra Ni / ethanol / 6 h / 25 °C
View Scheme
参考文献
Korodi, Ferenc; Jeko, Jozsef; Szabo, Zoltan
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1275 - 1281
反应条件
hydrogen iodide; acetic acid
T=275°C; im Rohr;
参考文献
Wohnlich
Archiv der Pharmazie (Weinheim, Germany), 1913 , vol. 251, p. 549
