3-乙酰基-3-氟二氢-2(3H)-呋喃酮合成路线 （共 4 条）
反应条件
triethylamine tris(hydrogen fluoride); triethylamine in acetonitrile
T=80°C; 3 h;
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
Location in patent: Paragraph 0108 ;
反应条件
fluorine in formic acid
T=10 - 15°C;
参考文献
Chambers, Richard D.; Greenhall, Martin P.; Hutchinson, John
Tetrahedron, 1996 , vol. 52, # 1 p. 1 - 8
反应条件
1: sulfuryl dichloride / 20 °C
2: triethylamine tris(hydrogen fluoride); triethylamine / acetonitrile / 3 h / 80 °C
View Scheme
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
反应条件
potassium iodide in 1-methyl-pyrrolidin-2-one
T=190°C; P=375.038 Torr;
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
Location in patent: Paragraph 0110 ;
