3-(1H-苯并咪唑-2-基)-丙酸乙酯合成路线 （共 7 条）
反应条件
ethanol; hydrazine hydrate
参考文献
Sorm; Urban
Collection of Czechoslovak Chemical Communications, 1950 , vol. 15, p. 196,200
反应条件
1: ethanol; N2H4+H2O 2: HCl 3: Hydrolysis View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 15, p. 196,200
反应条件
1: succinic acid anhydride; 1,2-diamino-benzene in 1,4-dioxane
T=20 - 80°C; 16 h;
2: ethanol With sulfuric acid
T=20°C; 20 h; Heating / reflux;
参考文献
OMEROS CORPORATION
Patent: WO2009/143178 A2, 2009 ;
Location in patent: Page/Page column 85 ;
WO 2009/143178 A2
反应条件
hydrogenchloride; ammonia in ethanol; water
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6114532 A1, 2000 ;
US 6114532 A
反应条件
hydrogenchloride
3 h;
参考文献
Gunes; Cosar
Arzneimittel-Forschung/Drug Research, 1992 , vol. 42, # 8 p. 1045 - 1048
反应条件
1: 76.8 percent / 4M HCl / 5 h / Heating
2: 80.4 percent / HCl / 3 h
View Scheme
参考文献
Gunes; Cosar
Arzneimittel-Forschung/Drug Research, 1992 , vol. 42, # 8 p. 1045 - 1048
反应条件
1: ethanol; N2H4+H2O
2: HCl
View Scheme
参考文献
Sorm; Urban
Collection of Czechoslovak Chemical Communications, 1950 , vol. 15, p. 196,200
