2-(2-嘧啶基)乙酸乙酯合成路线 （共 2 条）
反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide; mineral oil T=-78°C; 0.166667 h; 2: 2-pyrimidinyl chloride in N,N-dimethyl-formamide; mineral oil T=20 - 120°C; 90 h;
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; KARANEWSKY, Donald; WERNER, Sara; DARMOHUSODO, Vincent; YAMAMOTO, Jeff
Patent: WO2014/25706 A1, 2014 ;
Location in patent: Page/Page column 87 ;
反应条件
sodium hydroxide in ethanol T=20°C; 72 h; Inert atmosphere;
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; KARANEWSKY, Donald; WERNER, Sara; DARMOHUSODO, Vincent; YAMAMOTO, Jeff
Patent: WO2014/25706 A1, 2014 ;
Location in patent: Page/Page column 86; 87 ;
