3,6-二羟基-2-(3-甲基-3-丁烯-1-炔-1-基)苯甲醛合成路线 （共 18 条）
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 6 h;
参考文献
Goddard, Mary-Lorene; Tabacchi, Raffaele
Tetrahedron Letters, 2006 , vol. 47, # 6 p. 909 - 911
反应条件
tetrabutyl ammonium fluoride; acetic acid in tetrahydrofuran
T=0°C; 0.5 h; Yield given;
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: 35 percent / 1.) n-butyllithium, 2.) ethylene iodochloride / tetrahydrofuran / 1.) room temperature, 35 min, 2.) 0 deg C, 0.5 h
2: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
3: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
4: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
2: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
2: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
3: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: 1.) n-butyllithium, 2.) ethylene iodochloride / 1.) pentane, 0 deg C, 6 h, 2.) ether, from 0 deg C to 15 deg C, 2 h
2: 85 percent / Hg(OAc)2 / methanol / 0.5 h
3: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
4: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
5: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: 85 percent / Hg(OAc)2 / methanol / 0.5 h
2: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
3: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
4: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: imidazole / dimethylformamide / 10.5 h / 50 °C
2: dimethylformamide / 2 h / 90 - 107 °C
3: glacial acetic acid, tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
1: dimethylformamide / 2 h / 90 - 107 °C
2: glacial acetic acid, tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
反应条件
in N,N-dimethyl-formamide
T=70 - 90°C; 3 h;
参考文献
Ronald, Robert C.; Lansinger, Janet M.; Lillie, Thomas S.; Wheeler, Carl J.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2541 - 2549
