4,6-二羟基-5-硝基吡啶-3-羧酸乙酯合成路线 （共 10 条）
反应条件
nitric acid; acetic anhydride in water T=60 - 90°C; 20 h;
参考文献
BASILEA PHARMACEUTICA AG
Patent: WO2009/106419 A1, 2009 ;
Location in patent: Page/Page column 79 ;
反应条件
1: aqueous NaOH 2: water / 140 °C 3: phosphoryl chloride 4: ethanolic NH3 / 100 °C View Scheme
参考文献
Koegl et al.
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 29,37
反应条件
1: aqueous NaOH 2: water / 140 °C View Scheme
参考文献
Koegl et al.
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 29,37
反应条件
1: aqueous NaOH 2: water / 140 °C 3: phosphoryl chloride 4: ethanolic NH3 / 100 °C 5: Na2S; H2O View Scheme
参考文献
Koegl et al.
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 29,37
反应条件
1: 73 percent / POCl3 / 48 h / 115 °C 2: 94 percent / H2 / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr 3: 91 percent / hexafluorophosphoric acid, aq. NaNO2 / 0.08 h 4: 27 percent / 150 °C 5: 97 percent / 1.0 N aq. NaOH / tetrahydrofuran / 0.5 h / 5 - 20 °C View Scheme
参考文献
Sanchez; Gogliotti
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
反应条件
1: 73 percent / POCl3 / 48 h / 115 °C 2: 94 percent / H2 / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr 3: 91 percent / hexafluorophosphoric acid, aq. NaNO2 / 0.08 h 4: 27 percent / 150 °C View Scheme
参考文献
Sanchez; Gogliotti
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
反应条件
1: aqueous NaOH 2: water / 140 °C 3: phosphoryl chloride View Scheme
参考文献
Koegl et al.
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 29,37
反应条件
1: 73 percent / POCl3 / 48 h / 115 °C 2: 94 percent / H2 / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr View Scheme
参考文献
Sanchez; Gogliotti
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
反应条件
trichlorophosphate T=115°C; 48 h;
参考文献
Sanchez; Gogliotti
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
反应条件
N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate in acetonitrile
T=40°C; Reflux;
参考文献
Roche Palo Alto LLC
Patent: US2010/56535 A1, 2010 ;
Location in patent: Page/Page column 31 ;
