(4-氯苯基)(2-吡啶基)甲酮合成路线 （共 26 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: 4-chlorobenzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 3 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
manganese(IV) oxide in dichloromethane 4 h;
参考文献
Hirayama, Tasuku; Ueda, Satoshi; Okada, Takahiro; Tsurue, Norihiko; Okuda, Kensuke; Nagasawa, Hideko
Chemistry - A European Journal, 2014 , vol. 20, # 14 p. 4156 - 4162
反应条件
copper(l) iodide; oxygen; acetic acid in dimethyl sulfoxide T=100°C; 24 h;
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-90°C; 0.25 h; 2: 4-chlorobenzoic acid methyl ester in various solvents T=-110 - 20°C; 4 h;
参考文献
Popova, I. S.; Formanovsky, A. A.; Mikhura, I. V.
Russian Chemical Bulletin, 2002 , vol. 51, # 3 p. 540 - 543
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 2002 , # 3 p. 501 - 504
反应条件
sodium hydroxide; aluminium trichloride; thionyl chloride in water; chlorobenzene
反应条件
caesium carbonate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; palladium diacetate in 1,4-dioxane T=120°C; P=37503 Torr; 21 h;
参考文献
Tetrahedron, , vol. 63, # 3 p. 682 - 689
反应条件
1: pyridine With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl; boron trifluoride diethyl etherate in tetrahydrofuran T=-40°C; Inert atmosphere; 2: With CuCN*2LiCl in tetrahydrofuran T=-40°C; 0.5 h; Inert atmosphere; 3: 4-chloro-benzoyl chloride in tetrahydrofuran T=-40 - 25°C; Negishi coupling reaction; Inert atmosphere; regioselective reaction;
参考文献
Jaric, Milica; Haag, Benjamin A.; Unsinn, Andreas; Karaghiosoff, Konstantin; Knochel, Paul
Angewandte Chemie - International Edition, 2010 , vol. 49, # 32 p. 5451 - 5455
反应条件
1.1: Mg / iodine / tetrahydrofuran / 2 h / Heating 1.2: 96 percent / tetrahydrofuran / 2 h / 0 - 20 °C 2.1: 71 percent / pyridinium chlorochromate / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 2 p. 219 - 232
反应条件
1.1: Mg / iodine / tetrahydrofuran / 2 h / Heating 1.2: 96 percent / tetrahydrofuran / 2 h / 0 - 20 °C 2.1: 71 percent / pyridinium chlorochromate / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 2 p. 219 - 232
反应条件
NiO2 in tetrahydrofuran
参考文献
Journal of Organic Chemistry, , vol. 69, # 4 p. 1364 - 1367
