2-氨基-6-苯甲酰基-1-[(异丙基)磺酰基]-1H-苯并咪唑合成路线 (共 4 条)
反应条件
sodium hydroxide; sodium chloride; ammonium chloride in isopropyl alcohol
参考文献
Eli Lilly and Company
Patent: US4483986 A1, 1984 ;
反应条件
sodium hydride
1.) dimethoxyethane, RT, 1 h, 2.) dimethoxyethane, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Wikel, J. H.; Paget, C. J.; DeLong, D. C.; Nelson, J. D.; Wu, C. Y. E.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 368 - 372
反应条件
hydroxylamine hydrochloride in methanol
24 h; Heating; Yield given. Yields of byproduct given;
参考文献
Wikel, J. H.; Paget, C. J.; DeLong, D. C.; Nelson, J. D.; Wu, C. Y. E.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 368 - 372
反应条件
hydroxylamine hydrochloride in methanol
24 h; Heating; Yield given. Yields of byproduct given;
参考文献
Wikel, J. H.; Paget, C. J.; DeLong, D. C.; Nelson, J. D.; Wu, C. Y. E.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 368 - 372