反应条件
1: 100 percent / B(OMe)3, BMS / tetrahydrofuran / 72 h / Ambient temperature
2: 98 percent / PBr3 / CH2Cl2 / 16 h / Ambient temperature
3: 1.) n-BuLi / 1.) THF, HMPA, hexane, -78 deg C, 5 min, 2.) THF, HMPA, hexane, a) -78 deg C, 15 min, 2.) RT, 2 h
4: 87 percent / 1N HCl / tetrahydrofuran / 4 h / 0 °C
5: LiOH, LiBr, n-Bu4NBr / acetonitrile / 1 h / Ambient temperature
View Scheme
参考文献
Sagan, Sandrine; Josien, Hubert; Karoyan, Philippe; Brunissen, Alie; Chassaing, Gerard; Lavielle, Solange
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2167 - 2178
