7-羟基-2-甲基-4H-1-苯并吡喃-4-酮合成路线 （共 23 条）
反应条件
1: 90 percent / Br2 / CCl4 / Heating
2: toluene / Heating
3: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C
4: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h
View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
1: toluene / Heating
2: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C
3: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h
View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
参考文献
Rao et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 685
反应条件
1: ethyl acetate With sodium hydride in tetrahydrofuran
Reflux;
2: 1-(2,4-dihydroxy-phenyl)-ethanone in tetrahydrofuran; isopropyl alcohol
Reflux;
参考文献
Zhou, Ting; Ohkoshi, Emika; Shi, Qian; Bastow, Kenneth F.; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3219 - 3222
反应条件
in benzene
Irradiation;
参考文献
Garcia, Hermenegildo; Martinez-Utrilla, Roberto; Miranda, Miguel A.
Liebigs Annalen der Chemie, 1985 , # 3 p. 589 - 598
反应条件
1: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C
2: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h
View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
sodium hydroxide
1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
1: aqueous HF
2: aq. NaOH solution
View Scheme
参考文献
Dann et al.
Justus Liebigs Annalen der Chemie, 1954 , vol. 587, p. 16,36
反应条件
in benzene
Irradiation;
参考文献
Garcia, Hermenegildo; Martinez-Utrilla, Roberto; Miranda, Miguel Angel
Tetrahedron Letters, 1981 , vol. 22, # 18 p. 1749 - 1750
参考文献
Geissman
Journal of the American Chemical Society, 1951 , vol. 73, p. 3514
