1-氨基环己烷-1-羧酸乙酯盐酸盐合成路线 （共 4 条）
反应条件
1: CHCl3 / 3 h / 0 - 20 °C 2: 71 percent / tetrahydrofuran / 3 h / 0 - 20 °C 3: 85 percent / concd. HCl; glacial acetic acid / 5 h / Heating View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
hydrogenchloride
Heating;
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: in 1-methyl-pyrrolidin-2-one
1 h;
2: With phosphazene base P1-t-bu-tris(tetramethylene) in 1-methyl-pyrrolidin-2-one
T=20°C; 14 h;
3: With hydrogenchloride in tetrahydrofuran
5 h;
参考文献
Guino, Meritxell; Hii, King Kuok
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 17 p. 3188 - 3193
反应条件
1: CHCl3 / 3 h / 0 - 20 °C
2: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
