(3-三氟甲基苯氧基)乙醛合成路线 （共 12 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; Swern Oxidation; 0.5 h;
2: With triethylamine in dichloromethane
T=-78 - 0°C; 0.166667 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 59 ;
WO 2008/078291 A1
反应条件
diisobutylaluminium hydride in diethyl ether
T=-70°C;
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
反应条件
sulfuric acid in water; acetone
参考文献
Merck and Co., Inc.
Patent: US4018802 A1, 1977 ;
反应条件
sodium periodate; silica gel in dichloromethane; water
Heating;
参考文献
ScinoPharm Taiwan Ltd.
Patent: US2009/259058 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
sulfuric acid in tetrahydrofuran
Inert atmosphereHeatingReflux;
参考文献
ScinoPharm Taiwan Ltd.
Patent: US2009/259058 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
diisobutylaluminium hydride
T=-70°C;
参考文献
Danilova, N. A.; Miftakhov, M. S.; Lopp, M. I.; Lille, Yu. E.; Tolstikov, G. A.
Doklady Chemistry, 1983 , vol. 273, p. 375 - 377
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 3 p. 620 - 622
反应条件
diisobutylaluminium hydride
参考文献
Ling, Kah-Hiing John; Yang, Wu; Ni, Jinsong; Yuan, Haiqing; Tang-Liu, Diane D.S.
Patent: US2004/23954 A1, 2004 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 84.3 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 8 h / 140 - 150 °C
2: aq. H2SO4 / tetrahydrofuran / Heating
View Scheme
参考文献
Fox, Martin E.; Jackson, Mark; Lennon, Ian C.; McCague, Raymond; Parratt, Julian S.
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 1 p. 50 - 56
反应条件
sulfuric acid in tetrahydrofuran
Heating; Title compound not separated from byproducts.;
参考文献
Fox, Martin E.; Jackson, Mark; Lennon, Ian C.; McCague, Raymond; Parratt, Julian S.
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 1 p. 50 - 56
反应条件
1: 1) ethylbromide, Mg / 1) THF, colling with ice; 2) THF, 18 h, room temp.
2: 93 percent / imidazole / dimethylformamide / 1) 5 gradC, 1.5 h; 2) room temp., 18 h
View Scheme
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
