N-Cbz-D-苯丙氨醛合成路线 （共 20 条）
反应条件
sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium bromide in dichloromethane; water T=0 - 5°C;
参考文献
Pierce; Pierce, Michael E.; Harris; Harris, Gregory D.; Islam; Islam, Qamrul; Radesca; Radesca, Lilian A.; Storace; Storace, Louis; Waltermire; Waltermire, Robert E.; Wat; Wat, Ed; Jadhav; Jadhav, Prabhakar K.; Emmett; Emmett, George C.
Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 444 - 450
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 25°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 11 p. 2156 - 2169
参考文献
Organic Letters, , vol. 2, # 26 p. 4245 - 4247
反应条件
diisobutylaluminium hydride in toluene T=-78°C; 2 h;
参考文献
Liebigs Annales, , # 2 p. 235 - 238
反应条件
1: CH2Cl2 / 3 h / Ambient temperature 2: LAH / tetrahydrofuran / 1 h / 0 - 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 11 p. 2156 - 2169
反应条件
1: 64 percent / N-chlorosuccinimide, Et3N / methanol / 0 °C 2: 1.) O3, 2.) (CH3)2S / 1.) CH2Cl2, CH3OH, -78 deg C, 2.) CH2Cl2, CH3OH, from -78 deg C to 25 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 3 p. 417 - 419
反应条件
1: 89 percent / Et3N / tetrahydrofuran / 18 h / 20 °C 2: 81 percent / ethyldiisopropylamine; SO3/pyridine / CH2Cl2; dimethylsulfoxide / 0.5 h / cooling View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 24 p. 5449 - 5460
反应条件
1: 89 percent / Et3N / tetrahydrofuran / 18 h / 20 °C 2: 81 percent / ethyldiisopropylamine; SO3/pyridine / CH2Cl2; dimethylsulfoxide / 0.5 h / cooling View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 24 p. 5449 - 5460
反应条件
1: NaBH4, LiCl / ethanol; tetrahydrofuran 2: SO3 / pyridine; dimethylsulfoxide; triethylamine / 0.33 h / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 24 p. 2989 - 2992
反应条件
2: DIBAL-H / toluene / 2 h / -78 °C View Scheme
参考文献
Liebigs Annales, , # 2 p. 235 - 238
