2-氨基-4-甲基戊酸盐酸盐合成路线 （共 10 条）
反应条件
thionyl chloride T=20°C;
参考文献
Jeong, Yong-Chul; Moloney, Mark G.
Synlett, 2009 , # 15 p. 2487 - 2491
反应条件
hydrogenchloride in methanol
参考文献
Japan Science and Technology Corporation
Patent: US6339159 B1, 2002 ;
Location in patent: Example 3 ;
参考文献
US6048852 A1, ;
US 6048852 A
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) MeOH, 1 atm; 2.) ether; Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 28, # 11 p. 1215 - 1218
反应条件
1: 1.) trifluoromethanesulphonic acid anhydride / 1.) CH2Cl2, 0 deg C, 2.) 0 deg C to room temp. 2: 1.) hydrogen, 2.) HCl / 1.) Pd/C / 1.) MeOH, 1 atm; 2.) ether View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 11 p. 1215 - 1218
反应条件
1: 65.3 percent / triethylamine, isobutylchloroformate / acetonitrile / Ambient temperature 2: 64.7 percent / NaBH4, LiCl / tetrahydrofuran / 15 h / Ambient temperature View Scheme
参考文献
Arutyunyan, A. A.; Melik-Ogadzhanyan, R. G.; Alaverdova, L. G.; Papoyan, S. A.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 837 - 840
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1223 - 1226
反应条件
triethylamine; isobutyl chloroformate in acetonitrile Ambient temperature;
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 10 p. 837 - 840
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 10 p. 1223 - 1226
参考文献
Journal of the American Chemical Society, , vol. 105, # 26 p. 7703 - 7713
反应条件
pyridine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; toluene
参考文献
Lim-Wilby, Marguerita; Semple, Joseph Edward; Weinhouse, Michael I.; Goldman, Erick A.; Araldi, Gian L.
Patent: US2002/107266 A1, 2002 ;
反应条件
sodium carbonate in 1,4-dioxane; water
参考文献
SmithKline Beecham Corporation
Patent: US5998470 A1, 1999 ;
US 5998470 A
