4'-羟基-3'-硝基苯乙酮合成路线 （共 34 条）
反应条件
1: TBAI, K2CO3 / acetone 2: Br2 / CHCl3 View Scheme
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-Fang; Li, Xing-Shu
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1523 - 1526
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Martin, Richard; Flatt, Brenton Todd; Kahl, Jeffrey Dean; Wang, Tie-Lin
Patent: US2003/212111 A1, 2003 ;
US 20030212111 A1
反应条件
lithium hydroxide in tetrahydrofuran T=70°C; 1.5 h;
参考文献
Basak, Anindita; Nayak, Mrinal K.; Chakraborti, Asit K.
Tetrahedron Letters, 1998 , vol. 39, # 27 p. 4883 - 4886
参考文献
Zeegers, Petrus J.; Thompson, Malcolm J.
Magnetic Resonance in Chemistry, 1992 , vol. 30, # 6 p. 497 - 499
反应条件
1: 1-[4-hydroxy-3-nitrophenyl]ethanone With potassium carbonate in water; acetone T=20°C; 2: benzyl chloride With potassium iodide in water; acetone 17 h; Reflux;
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-Fang; Li, Xing-Shu
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1523 - 1526
反应条件
1: 1-[4-hydroxy-3-nitrophenyl]ethanone With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 2: benzyl bromide in acetonitrile T=20°C; 3 h; Reflux;
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1: caesium carbonate / N,N-dimethyl-formamide 2: iron; acetic acid View Scheme
参考文献
Gangloff, Anthony R.; Brown, Jason; De Jong, Ron; Dougan, Douglas R.; Grimshaw, Charles E.; Hixon, Mark; Jennings, Andy; Kamran, Ruhi; Kiryanov, Andre; O'Connell, Shawn; Taylor, Ewan; Vu, Phong
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4501 - 4505
反应条件
1.1: potassium carbonate / water; acetone / 20 °C 1.2: 17 h / Reflux 2.1: bromine / acetic acid / 20 °C 3.1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; sodium formate / water / 2 h / 20 - 40 °C / Inert atmosphere 4.1: 5 platinum on carbon; dimethylsulfide; hydrogen / tetrahydrofuran / 12 h / 40 °C / 25858.1 Torr 5.1: acetic anhydride / tetrahydrofuran / 1 h / 10 - 20 °C View Scheme
参考文献
Huang, Ling; Shan, Wenjun; Zhou, Qi; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 249 - 253
反应条件
1.1: potassium carbonate / water; acetone / 20 °C 1.2: 17 h / Reflux 2.1: bromine / acetic acid / 20 °C 3.1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; sodium formate / water / 2 h / 20 - 40 °C / Inert atmosphere View Scheme
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-Fang; Li, Xing-Shu
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1523 - 1526
反应条件
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 1.2: 3 h / 20 °C / Reflux 2.1: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 4 h 3.1: BH3*N,N-diethylanilline; (1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol / tetrahydrofuran / 3.5 h / 3 - 5 °C View Scheme
参考文献
Huang, Ling; Shan, Wenjun; Zhou, Qi; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 249 - 253
