4'-羟基-3'-硝基苯乙酮合成路线 （共 34 条）
反应条件
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
1.2: 3 h / 20 °C / Reflux
2.1: platinum(IV) oxide; hydrogen / tetrahydrofuran; toluene / 24 h / 25 °C / 772.58 Torr
3.1: pyridine / acetonitrile / 1 h / 25 °C
4.1: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 1.75 h / 25 °C
View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
hydrogen; palladium 10 on activated carbon in methanol; DMF (N,N-dimethyl-formamide)
P=1551.49 Torr; 2 h;
参考文献
NICHOLAS PIRAMAL INDIA LIMITED
Patent: WO2005/35495 A2, 2005 ;
Location in patent: Page/Page column 90 ;
反应条件
1: H2 / Pd-C / methanol / 760 Torr / Ambient temperature
2: Py / benzene / Heating
View Scheme
参考文献
Hansen, Peter; Pettersson, Lars
Patent: US2003/144267 A1, 2003 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C
2: iron / acetic acid / 1 h / 80 °C
3: triethylsilane / trifluoroacetic acid / 2 h / 80 °C
View Scheme
参考文献
Gangloff, Anthony R.; Brown, Jason; De Jong, Ron; Dougan, Douglas R.; Grimshaw, Charles E.; Hixon, Mark; Jennings, Andy; Kamran, Ruhi; Kiryanov, Andre; O'Connell, Shawn; Taylor, Ewan; Vu, Phong
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4501 - 4505
