3-环己基-2-巯基-噻唑烷-4-酮合成路线 (共 3 条)
反应条件
1: bis(carboxymethyl) trithiocarbonate With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; 1.5 h;
2: cyclohexylamine in tetrahydrofuran
4 h; Reflux;
参考文献
Harada, Koichiro; Kubo, Hideki; Abe, Jun; Haneta, Mari; Conception, Arnel; Inoue, Shinichi; Okada, Satoshi; Nishioka, Kazuhiko
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3242 - 3254
反应条件
1: carbon disulfide; cyclohexylamine With sodium hydroxide
T=100°C; 0.0833333 h; Microwave irradiation;
2: chloroacetic acid T=40 - 100°C; 0.0833333 h;
3: With hydrogenchloride in water
T=40 - 120°C; 0.5 h;
参考文献
Nitsche, Christoph; Schreier, Verena N.; Behnam, Mira A. M.; Kumar, Anil; Bartenschlager, Ralf; Klein, Christian D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8389 - 8403
反应条件
hydrogenchloride; iso-propyl nitrite in ethanol
参考文献
Brown,F.C. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1239 - 1243