3-氨基-3-(5-氯-2-硝基苯基)-丙酸合成路线 （共 4 条）
反应条件
sodium hydroxide; hydrazine hydrate; nickel T=80°C; 0.5 h;
参考文献
Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2155 - 2162
反应条件
1: 89 percent / 1.) 5percent aq. NaOH, 2.) hydrazine hydrate / 2.) Raney nickel / 0.5 h / 80 °C 2: 71 percent / conc. H2SO4 / 4 h / Heating View Scheme
参考文献
Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2155 - 2162
反应条件
hydrogenchloride; sodium hydroxide; formic acid; malonic acid; ammonium formate in water
参考文献
Adir et Compagnie
Patent: US5703070 A1, 1997 ;
反应条件
hydrogenchloride; formic acid; ammonium formate
Yield given. Multistep reaction;
参考文献
Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2155 - 2162
