5-氨基-1H-吡唑-3-羧酸甲酯合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr; 24 h;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.
Patent: WO2011/79230 A2, 2011 ;
Location in patent: Page/Page column 60; 61 ;
WO 2011/079230 A1
反应条件
methyl 3-(tert-butoxycarbonylamino)-1H-pyrazole-5-carboxylate in 1,4-dioxane 2 h; Reflux;
参考文献
Synthetic Communications, , vol. 39, # 22 p. 4122 - 4132
反应条件
hydrogenchloride in ethanol; water T=20°C; 6 h;
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
Location in patent: Page/Page column 41 ;
WO 2011/015343 A1
反应条件
ammonia in methanol
T=20 - 80°C; 1 h;
参考文献
NEOGENESIS PHARMACEUTICALS, INC.
Patent: WO2003/101993 A1, 2003 ;
Location in patent: Page 66-68 ;
WO 03/101993 A1
反应条件
1: With lithium borohydride in tetrahydrofuran
16 h; Heating / reflux;
2: With methanol in tetrahydrofuran
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/99326 A1, 2007 ;
Location in patent: Page/Page column 116 ;
WO 2007/099326 A1
