2-氨基-5-氯-3-硝基苯甲酸合成路线 （共 17 条）
反应条件
1: 82 percent / conc. H2SO4; KNO3 / 24 h / 20 °C
2: 82 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 2.0 g / cc. nitric acid / H2SO4 / 1 h / 0 °C
2: 1.40 g / cc. hydrochloric acid / H2O / 1 h / Heating
View Scheme
参考文献
Deady, Leslie W.; Kaye, Anthony J.
Australian Journal of Chemistry, 1997 , vol. 50, # 5 p. 473 - 478
反应条件
water
Heating; Yield given;
参考文献
Flippin; Carter; Berger; Clark; Bonhaus; Leung; Eglen
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 4 p. 477 - 480
反应条件
1: NaNO3, H2SO4
2: H2O / Heating
View Scheme
参考文献
Flippin; Carter; Berger; Clark; Bonhaus; Leung; Eglen
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 4 p. 477 - 480
反应条件
1: aqueous potassium permanganate; magnesium sulfate
2: aqueous hydrochloric acid
View Scheme
参考文献
Tsuda; Oguri
Yakugaku Zasshi, 1942 , vol. 62, p. 66,68; dtsch. Ref. S. 24
Chem.Abstr., 1951 , p. 1580
Full Text Show Details
Magidson; Golowtschinskaja
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 1797,1801
Chem. Zentralbl., 1940 , vol. 111, # I p. 370
反应条件
in methanol; diethyl ether
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 96-97 ;
WO 2010/115736 A2
反应条件
1: SOCl2 / 3 h / Heating
2: 172 mg / 12 h / 20 °C
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
