2-氨基-5-甲基噻唑-4-甲酸甲酯合成路线 （共 5 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C;
参考文献
US2010/29690 A1, ;
Page/Page column 40 ;
US 20100029690 A1
反应条件
1: acetaldehyde; dichloroacetic acid ethyl ester With sodium methylate in diethyl ether 2: methanol; thiourea Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3732 - 3736
参考文献
US6344562 B1, ;
Page column 73 ;
反应条件
tert.-butylnitrite in tetrahydrofuran
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
1: NaNO2; H3PO2 2: aq. LiOH / methanol View Scheme
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
