1-苄基-4-甲基哌嗪-2-羧酸乙酯合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/37810 A1, 2004 ;
Location in patent: Page/Page column 113-114 ;
WO 2004/037810 A1
反应条件
1: K2CO3, KI / acetone / 15 h / Ambient temperature
2: conc. HCl / acetone / 3 h / Ambient temperature
3: HCO2H / methanol; H2O / 20 h / Heating
View Scheme
参考文献
Rondu, Frederic; Bihan, Gaelic Le; Wang, Xuan; Lamouri, Aazdine; Touboul, Estera; Dive, Georges; Bellahsene, Tounes; Pfeiffer, Bruno; Renard, Pierre; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Penicaud, Luc; Ktorza, Alain; Godfroid, Jean-Jacques
Journal of Medicinal Chemistry, 1997 , vol. 40, # 23 p. 3793 - 3803
反应条件
1: conc. HCl / acetone / 3 h / Ambient temperature
2: HCO2H / methanol; H2O / 20 h / Heating
View Scheme
参考文献
Rondu, Frederic; Bihan, Gaelic Le; Wang, Xuan; Lamouri, Aazdine; Touboul, Estera; Dive, Georges; Bellahsene, Tounes; Pfeiffer, Bruno; Renard, Pierre; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Penicaud, Luc; Ktorza, Alain; Godfroid, Jean-Jacques
Journal of Medicinal Chemistry, 1997 , vol. 40, # 23 p. 3793 - 3803
反应条件
formic acid in methanol; water
20 h; Heating;
参考文献
Rondu, Frederic; Bihan, Gaelic Le; Wang, Xuan; Lamouri, Aazdine; Touboul, Estera; Dive, Georges; Bellahsene, Tounes; Pfeiffer, Bruno; Renard, Pierre; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Penicaud, Luc; Ktorza, Alain; Godfroid, Jean-Jacques
Journal of Medicinal Chemistry, 1997 , vol. 40, # 23 p. 3793 - 3803
反应条件
triethylamine in benzene
3 h; Heating;
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=2844.31 Torr; 18 h;
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
