(R)-(+)-2-氨基-2-苯乙酰胺 盐酸盐合成路线 （共 9 条）
反应条件
hydrogenchloride in 1,4-dioxane; methanol
参考文献
Aton Pharma, Inc.
Patent: US2011/104765 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
hydrogenchloride in water T=110°C; 20 h;
参考文献
Chen, Jianxin; Pandey, Rajesh K.; Cunico, Robert F.
Tetrahedron Asymmetry, 2005 , vol. 16, # 5 p. 941 - 947
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 60 ;
反应条件
1.1: BF3*Et2O / benzene / 40 h 1.2: 52 percent / H2O 2.1: 80 percent / hydrogen / Pd/C / methanol / 10 h / 25 °C / 760 Torr 3.1: 75 percent / HCl / H2O / 20 h / 110 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 5 p. 941 - 947
反应条件
1: 80 percent / hydrogen / Pd/C / methanol / 10 h / 25 °C / 760 Torr 2: 75 percent / HCl / H2O / 20 h / 110 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 5 p. 941 - 947
反应条件
potassium carbonate in water
参考文献
US2006/223855 A1, ;
Page/Page column 137 ;
反应条件
potassium carbonate in water
参考文献
US2006/223855 A1, ;
Page/Page column 137 ;
反应条件
potassium carbonate in water
参考文献
US2006/223855 A1, ;
Page/Page column 137 ;
反应条件
1.1: water; methanol / 20 h / 40 °C / Sealed tube 2.1: sulfuric acid / dichloromethane; water / 3.25 h / -10 - 0 °C / Cooling with ice 2.2: pH 8 - 9 3.1: ammonium formate / palladium on carbon / isopropyl alcohol / 1 h / Inert atmosphere; Reflux View Scheme
