3-(3-硝基苯基)-1-丙醇合成路线 （共 9 条）
反应条件
1: With borane-THF in tetrahydrofuran
T=20°C; Cooling with ice;
2: With water in tetrahydrofuran
Cooling;
参考文献
INCYTE CORPORATION
Patent: US2010/190804 A1, 2010 ;
Location in patent: Page/Page column 73 ;
US 20100190804 A1
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 0.25 h;
参考文献
Dalla, Vincent; Decroix, Bernard
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1657 - 1660
反应条件
lithium borohydride; 1-n-decene in tetrahydrofuran
T=20°C; 18 h; Inert atmosphere;
参考文献
Pinto, Orlando; Sardinha, Joao; Vaz, Pedro D.; Piedade, Fatima; Calhorda, Maria J.; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S. J.; Rauter, Amelia P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3175 - 3187
反应条件
1: 71 percent / (H2NOH)2, H2SO4, H2NOSO3H, NaOH / H2O / 5.5 h / 10 °C / pH 6-7
2: 72 percent / BF3 / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Strawn; Martell; Simpson; Leach; Counsell
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2104 - 2110
反应条件
diisobutylaluminium hydride
参考文献
Peng, Weimin; Blagg, Brian S. J.
Organic Letters, 2006 , vol. 8, # 5 p. 975 - 978
反应条件
1: potassium diazodicarboxylate
2: diisobutylaluminum hydride
View Scheme
参考文献
Peng, Weimin; Blagg, Brian S. J.
Organic Letters, 2006 , vol. 8, # 5 p. 975 - 978
反应条件
1: sodium hydride / tetrahydrofuran
2: sodium chloride / dimethyl sulfoxide
3: diisobutylaluminium hydride
View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
1: sodium chloride / dimethyl sulfoxide
2: diisobutylaluminium hydride
View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=2585.81 Torr;
参考文献
INCYTE CORPORATION
Patent: US2010/190804 A1, 2010 ;
Location in patent: Page/Page column 74 ;
US 20100190804 A1
