[D-蛋氨酰2,脯氨酰5]-脑啡肽酰胺合成路线 (共 8 条)
反应条件
hydrogenchloride; acetic acid in various solvent(s)
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
2: HCl, acetic acid / various solvent(s) / 1.5 h
3: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
4: NH3 / methanol
5: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: HCl, acetic acid / various solvent(s) / 1.5 h
2: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
3: NH3 / methanol
4: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: H2O, NaOH / methanol
2: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
3: NH3 / methanol
4: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / formamide
2: H2O, NaOH / methanol
3: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
4: NH3 / methanol
5: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: H2O, NaOH
2: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / formamide
3: H2O, NaOH / methanol
4: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
5: NH3 / methanol
6: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
2: H2O, NaOH
3: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / formamide
4: H2O, NaOH / methanol
5: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
6: NH3 / methanol
7: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
反应条件
1: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
2: NH3 / methanol
3: HCl, acetic acid / various solvent(s)
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177