4-(2-氯-4-吡啶)- 1- 哌嗪羧酸 1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
T=85°C; 20 h; Inert atmosphere;
参考文献
JANSSEN PHARMACEUTICA NV
Patent: WO2009/152325 A1, 2009 ;
Location in patent: Page/Page column 47-48 ;
WO 2009/152325 A1
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=120°C;
参考文献
Gobbi, Luca; Jaeschke, Georg; Rodriguez Sarmiento, Rosa Maria; Steward, Lucinda
Patent: US2010/75979 A1, 2010 ;
Location in patent: Page/Page column 9; 11 ;
US 20100075979 A1
反应条件
sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in toluene
T=100°C; 18 h; SealedInert atmosphere;
参考文献
ALMAC DISCOVERY LIMITED; HARRISON, Timothy; BURKAMP, Frank; JORDAN, Linda; BELL, Mark; JANSSEN, Dominic; MIEL, Hugues; MCFARLAND, Mary
Patent: WO2012/69852 A1, 2012 ;
Location in patent: Page/Page column 36 ;
