5-溴-2,3-二氟苯甲醛合成路线 （共 3 条）
反应条件
N-bromosuccinmide; sulfuric acid in water
T=60°C; 3 h; Inert atmosphere;
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 229 ;
反应条件
water; cesium fluoride in DMF (N,N-dimethyl-formamide)
T=20°C; 1 h;
参考文献
Eisai Co., Ltd.
Patent: EP1510516 A1, 2005 ;
Location in patent: Page/Page column 92 ;
反应条件
sodium tetrahydroborate; ammonium carbonate in ethanol
0.5 h;
参考文献
Jarchow-Choy, Sarah K.; Sjuvarsson, Elena; Sintim, Herman O.; Eriksson, Staffan; Kool, Eric T.
Journal of the American Chemical Society, 2009 , vol. 131, p. 5488 - 5494
