2-羟基-4-甲氧甲基-4-甲基烟腈合成路线 （共 5 条）
反应条件
1: acetic acid anhydride; fuming HNO3 2: chlorobenzene; PCl5 3: platinum; palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Bruce; Coover
Journal of the American Chemical Society, 1944 , vol. 66, p. 2092
反应条件
1: acetic acid anhydride; fuming HNO3
2: chlorobenzene; PCl5
View Scheme
参考文献
Bruce; Coover
Journal of the American Chemical Society, 1944 , vol. 66, p. 2092
反应条件
sulfuric acid
T=18 - 20°C;
参考文献
Shul'ga, N. A.; Balyakina, M. V.; Gunar, V. I.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 665 - 669
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1111 - 1115
反应条件
1: 70.5 percent / conc. H2SO4, fuming HNO3 / 0.5 h / 18 - 24 °C
2: 65 percent / conc. HCl / 5 h / Heating
View Scheme
参考文献
Shul'ga, N. A.; Balyakina, M. V.; Gunar, V. I.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 665 - 669
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1111 - 1115
反应条件
1: chlorobenzene; PCl5
2: palladium/charcoal; aq.-ethanolic HCl / 2206.5 Torr / Hydrogenation
View Scheme
参考文献
Mariella; Belcher
Journal of the American Chemical Society, 1952 , vol. 74, p. 4049
