5-甲酰基-4-甲基-1H-吡咯-3-羧酸乙酯合成路线 （共 8 条）
反应条件
1: aqueous-alcoholic KOH-solution 2: 190 - 200 °C View Scheme
参考文献
Fischer; Wiedemann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 61
反应条件
T=150 - 160°C; im Rohr;
参考文献
Fischer; Wiedemann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 61
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0 - 20°C; 1 h;
2: 4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
3: With water; sodium hydroxide in N,N-dimethyl-formamide
T=60°C; pH=7 - 8; 2 h; Cooling with ice;
参考文献
Jin, Yun-Zhou; Fu, Da-Xu; Ma, Nan; Li, Zhan-Cheng; Liu, Quan-Hai; Xiao, Lin; Zhang, Rong-Hua
Molecules, 2011 , vol. 16, # 11 p. 9368 - 9385
反应条件
hydrogenchloride; diethyl ether; zinc cyanide
Erwaermen des Reaktionsprodukts mit H2O;
参考文献
Corwin; Kleinspehn
Journal of the American Chemical Society, 1953 , vol. 75, p. 2089,2093
反应条件
diethyl ether; hydrogen cyanide; hydrogen bromide
Erwaermen des Reaktionsprodukts mit H2O;
参考文献
Corwin; Kleinspehn
Journal of the American Chemical Society, 1953 , vol. 75, p. 2089,2093
反应条件
1.1: sodium hydride / diethyl ether; dimethyl sulfoxide / 20 °C / Inert atmosphere
2.1: trichlorophosphate / 1 h / 0 - 20 °C
2.2: 1 h / 0 - 20 °C
2.3: 2 h / 60 °C / pH 7 - 8 / Cooling with ice
View Scheme
参考文献
Jin, Yun-Zhou; Fu, Da-Xu; Ma, Nan; Li, Zhan-Cheng; Liu, Quan-Hai; Xiao, Lin; Zhang, Rong-Hua
Molecules, 2011 , vol. 16, # 11 p. 9368 - 9385
反应条件
hydrogenchloride; diethyl ether
Erwaermen des entstandenen Imid-Hydrochlorids mit Wasser;
参考文献
Fischer; Wiedemann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 61
反应条件
1: 69 percent / 1 h / 230 °C
2: 73 percent / phosphorus oxychloride / 0.25 h / Heating
View Scheme
参考文献
Bonnett, Raymond; Hamzetash, Dariush; Valles, Maria Asuncion
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1383 - 1388
