(S)-2-甲基-2-吡咯烷羧酸合成路线 （共 5 条）
反应条件
1: 5N NaOH / 3.5 h / 5 to 10 deg C 2: 1) ethyl chloroformate, NEt3, 2) 25percent NH3 / 1) CHCl3, 2) H2O, 2h 3: 88 percent / H2 / 5percent Pd-C / ethanol / 760 Torr 4: 73 percent / conc. HCl / 18 h / Heating View Scheme
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
反应条件
hydrogen bromide
8 h; Ambient temperature;
参考文献
Seebach,D.; Boes,M.; Naef,R.
Journal of the American Chemical Society, 1983 , vol. 105, p. 5390
反应条件
triethylamine in 1,4-dioxane; water
5 h;
参考文献
Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley Kwan Mung; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried Heinz; Romines III, William Henry; Wallace, Michael B.; Yang, Yi
Patent: US2003/225147 A1, 2003 ;
Location in patent: Page 45 ;
反应条件
sodium hydroxide in water; N,N-dimethyl-formamide
Heating;
参考文献
Thaisrivongs; Pals; Lawson; Turner; Harris
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 536 - 541
反应条件
sodium hydroxide
3.5 h; 5 to 10 deg C;
参考文献
Shatzmiller, Shimon; Dolithzky, Ben-Zion; Bahar, Eliezer
Liebigs Annalen der Chemie, 1991 , # 4 p. 375 - 379
