1,2,3-三甲氧基苯合成路线 （共 210 条）
反应条件
1: AlCl3 / diethyl ether
2: aq. NH3 / dioxane
View Scheme
参考文献
Achmatowicz,O.; Achmatowicz,O.
Roczniki Chemii, 1961 , vol. 35, p. 813 - 820
反应条件
(i) nBuLi, THF, (ii) /BRN= 1209224/; Multistep reaction;
参考文献
Schill,G.; Logemann,E.
Chemische Berichte, 1973 , vol. 106, p. 2910 - 2917
反应条件
1: 1.) aluminium chloride, 2.) sodium dithionite, sodium hydroxide / 1.) 1,1,2,2-tetrachloroethane, room temperature, 16 h; steam-bath, 2 h, 2.) methanol, room temperature, 21 h, reflux, 24 h
2: 88 percent / hydrogen / palladium-carbon / acetic acid / 1.5 h / Ambient temperature
3: 59 percent / lithium aluminium hydride / diethyl ether
4: 62 percent / pyridine
5: 80 percent / lithium bromide / acetone / 24 h / Ambient temperature
6: magnesium (from magnesium chloride and potassium metal, 3-(4-methoxyphenyl)propanal / tetrahydrofuran
7: 74 percent / pyridinium chlorochromate / CH2Cl2 / 4.5 h
8: 54 percent / hydrogen chloride / CH2Cl2 / 0.5 h / -25 °C
View Scheme
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
反应条件
tin(IV) chloride in dichloromethane
2 h; Ambient temperature;
参考文献
Arriortua, M. I.; Via, J.; Urtiaga, M. K.; Dominguez, E.; Igartua, A.; Sotomayor, N.
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 5 p. 361 - 366
反应条件
trifluorormethanesulfonic acid in dichloromethane
T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
Rafiq, Settu Muhamad; Sivasakthikumaran, Ramakrishnan; Mohanakrishnan, Arasambattu K.
Organic Letters, 2014 , vol. 16, # 10 p. 2720 - 2723
反应条件
1.1: PPh3 / Pd(OAc)2 / tetrahydrofuran / 0.25 h / Heating
1.2: 70.4 mg / TBAF / tetrahydrofuran / 0.5 h / Heating
View Scheme
参考文献
Seganish, W. Michael; Handy, Christopher J.; DeShong, Philip
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8948 - 8955
反应条件
1: 61 percent / aq. HNO3 / ethanol / 3 h / Ambient temperature
2: 75 percent / Br2 / CHCl3 / 5 h / Ambient temperature
View Scheme
参考文献
Bock, Hans; Nick, Sabine; Seitz, Wolfgang; Naether, Christian; Bats, Jan W.
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1996 , vol. 51, # 2 p. 153 - 171
反应条件
1: polyphosphoric acid / 1.5 h / 80 °C
2: boron tribromide / dichloromethane / 24 h / 0 - 25 °C / Inert atmosphere
View Scheme
参考文献
Cetinkaya, Yasin; Goecer, Huelya; Menzek, Abdullah; Guelcin, Ilhami
Archiv der Pharmazie, 2012 , vol. 345, # 4 p. 323 - 334
反应条件
nitronium tetrafluoroborate in ethylene glycol dimethyl ether
T=-50°C;
参考文献
Dwyer; Holzapfel
Tetrahedron, 1998 , vol. 54, # 27 p. 7843 - 7848
参考文献
Will
Chemische Berichte, 1888 , vol. 21, p. 615
