2-氯-6-甲氧基-4-甲基-喹啉合成路线 （共 12 条）
反应条件
trichlorophosphate T=110 - 120°C; 0.5 h;
参考文献
Liu, Ying; Feng, Yabing; Wang, Renxiao; Gao, Ying; Lai, Luhua
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1639 - 1641
反应条件
1: 62.4 percent / H2SO4 / 2 h / 90 - 110 °C 2: 89.3 percent / POCl3 / 0.5 h / 110 - 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 13 p. 1639 - 1641
反应条件
1: 73.8 percent / 0.5 h / 140 °C 2: 62.4 percent / H2SO4 / 2 h / 90 - 110 °C 3: 89.3 percent / POCl3 / 0.5 h / 110 - 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 13 p. 1639 - 1641
反应条件
potassium hydroxide; ethanol; nickel T=60 - 70°C; Hydrogenation;
参考文献
Ainley; King
Pr. roy. Soc. <B>, 1938 , vol. 125, p. 60,84
反应条件
1: methanol / 43 h / Reflux; Inert atmosphere 2: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere View Scheme
参考文献
Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 131 - 142
反应条件
1.1: methanol / 43 h / Reflux; Inert atmosphere 2.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere 3.1: phosphorous pentoxide / diethylphosphoric acid ethyl ester / 1 h / 20 °C / Inert atmosphere 3.2: 0.25 h / 35 °C / Reflux; Inert atmosphere View Scheme
参考文献
Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 131 - 142
反应条件
potassium hydroxide T=160°C; 4 h;
参考文献
Liu, Ying; Feng, Yabing; Wang, Renxiao; Gao, Ying; Lai, Luhua
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1639 - 1641
反应条件
1: 80.8 percent / KOH / 4 h / 160 °C 2: 20.1 percent / ZnCl2 / 3 h / 160 °C 3: 74.6 percent / OsO4; NaIO4 / 24 h / 24 - 26 °C 4: 95.6 percent / AgNO3; NaOH / 12 h / 20 °C 5: 100 percent / (COCl)2 / 24 h / 20 °C 6: 92 percent / diethyl ether / 3 h / 0 - 15 °C View Scheme
参考文献
Liu, Ying; Feng, Yabing; Wang, Renxiao; Gao, Ying; Lai, Luhua
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1639 - 1641
反应条件
pyridine; potassium carbonate; copper(II) oxide
28 h; Heating;
参考文献
Singh, S. P.; Vaid, R. K.; Prakash, I.; Prakash, O.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 945 - 950
参考文献
Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP2003131 A1, 2008 ;
Location in patent: Page/Page column 64 ;
EP 2003131 A1
