3-(4-溴苯甲酰)丙酸合成路线 （共 54 条）
参考文献
Lutz; Scott
Journal of Organic Chemistry, 1948 , vol. 13, p. 284,292
反应条件
1: N2H4, KOH / bis-(2-hydroxy-ethyl) ether 2: polyphosphoric acid 3: (i), (ii) (heating), (iii) 2,3,5,6-tetrachloro-<1,4>benzoquinone View Scheme
参考文献
Bonnier,J.-M.; Rinaudo,J.
Bulletin de la Societe Chimique de France, 1971 , p. 2092 - 2094
反应条件
1: 94 percent / Clemmensen procedure 2: 100 percent / PPA / 0.25 h / 90 °C 3: hydroxylamine hydrochloride, NaOH / ethanol; H2O / Heating 4: 60 percent / conc.H2SO4, acetic anhydride / acetic acid / 0.5 h / 60 - 95 °C 5: 1.) NaNO2, aq. HCl, 2.) NaBF4 6: xylene / Heating 7: 1.) Mg, 2.) CuCl / 1.) diethyl ether, reflux, 2h, 2.) -17 deg C 8: 87 percent / 2 M aq. NaOH 9: 52 percent / polyphosphoric acid / 0.13 h / 90 °C 10: 54 percent / hydroxylamine hydrochloride, NaOH / ethanol View Scheme
参考文献
Mallory, Frank B.; Luzik, Eddie D.; Mallory, Clelia W.; Carroll, Patrick J.
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 366 - 370
反应条件
1: 84 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamido)pyridine / CH2Cl2 / 20 °C
2: 47 percent / Lawesson's reagent / toluene / 11.3 h / Heating
View Scheme
参考文献
Sonpatki; Herbert; Sandvoss; Seed
Journal of Organic Chemistry, 2001 , vol. 66, # 22 p. 7283 - 7286
反应条件
1: amalgamated zinc; aqueous hydrochloric acid; toluene / weiteres Reagens: Essigsaeure
2: thionyl chloride
View Scheme
参考文献
Fieser; Seligman
Journal of the American Chemical Society, 1938 , vol. 60, p. 170,174
反应条件
1: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux
2: trichlorophosphate / 6 h / Heating
View Scheme
参考文献
Islam, Mojahidul; Siddiqui, Anees A.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 5 p. 555 - 562
反应条件
sodium hydroxide
1 h; Ambient temperature;
参考文献
Cignarella, Giorgio; Grella, Giuseppe; Curzu, Maria Michela
Synthesis, 1980 , # 10 p. 825 - 828
反应条件
sodium hydroxide
1 h; Ambient temperature;
参考文献
Cignarella, Giorgio; Grella, Giuseppe; Curzu, Maria Michela
Synthesis, 1980 , # 10 p. 825 - 828
反应条件
sodium hydroxide
1 h; Ambient temperature;
参考文献
Cignarella, Giorgio; Grella, Giuseppe; Curzu, Maria Michela
Synthesis, 1980 , # 10 p. 825 - 828
反应条件
1.1: 82 percent / KOH; hydrazine monohydrate / triethylene glycol / 90 - 200 °C
2.1: 75 percent / polyphosphoric acid / 1 h / 80 °C
3.1: p-toluenesulfonic acid monohydrate; trimethyl orthoformate / methanol; benzene / 40 h / Heating
3.2: 75 percent / p-toluenesulfonic acid monohydrate / benzene / 4 h / Heating
4.1: n-BuLi / tetrahydrofuran; pentane / 0.67 h / -78 °C
4.2: 78 percent / tetrahydrofuran; pentane / 1.25 h / cooling
5.1: 85 percent / boron tribromide / CH2Cl2 / -35 - 0 °C
View Scheme
参考文献
Heller, Douglas P.; Goldberg, Daniel R.; Wu, Hongqiao; Wulff, William D.
Canadian Journal of Chemistry, 2006 , vol. 84, # 10 p. 1487 - 1503
