alpha-甲基-4-联苯乙酸合成路线 （共 34 条）
反应条件
n-butyllithium; diisopropylamine; lithium diisopropyl amide in tetrahydrofuran; hexane; water
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US4914112 A1, 1990 ;
反应条件
cobalt(II)salen; tetra-n-butylammonium perchlorate in N,N-dimethyl-formamide T=5°C; P=760 Torr; Electrochemical reaction;
参考文献
Damodar; Krishna Mohan; Khaja Lateef; Jayarama Reddy
Synthetic Communications, 2005 , vol. 35, # 9 p. 1143 - 1150
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux;
参考文献
Yamauchi, Takayoshi; Nakao, Kenji; Fujii, Kyoichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1433 - 1436
反应条件
1: (1,1-biphenyl)-4-acetic acid With lithium diisopropyl amide in tetrahydrofuran; hexane T=-84°C; 2 h; 2: methyl iodide in tetrahydrofuran; hexane T=-84 - 25°C; 5 h;
参考文献
Fairlamb, Ian J.S.; Dickinson, Julia M.; O'Connor, Rachael; Higson, Seamus; Grieveson, Lynsey; Marin, Veronica
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 8 p. 2641 - 2656
反应条件
pyridine; sulfur dioxide; chlorine in dichloromethane
反应条件
3-chloro-benzenecarboperoxoic acid in tetrahydrofuran T=25°C; 24 h;
参考文献
Uemura, Sakae; Ohe, Kouichi; Yamauchi, Takayoshi; Mizutaki, Shoichi; Tamaki, Kentaro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 907 - 910
反应条件
1: With magnesium; mercury dichloride in methanol T=20°C; 24 h; 2: With potassium hydroxide in methanol T=20°C; 24 h; Further stages.;
参考文献
Costa, Ana; Najera, Carmen; Sansano, Jose M.
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5216 - 5225
反应条件
sodium hydroxide in water Heating;
参考文献
Uemura, Sakae; Fukuzawa, Shin-ichi; Yamauchi, Takayoshi; Hattori, Kaneaki; Mizutaki, Shoichi; Tamaki, Kentaro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1983 - 1987
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux;
参考文献
Yamauchi, Takayoshi; Nakao, Kenji; Fujii, Kyoichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1433 - 1436
反应条件
1: With potassium tert-butylate in tetrahydrofuran; toluene T=-78 - 20°C; P=760.051 Torr; 3 h; 2: With hydrogenchloride in tetrahydrofuran; water; toluene
参考文献
Chemistry - A European Journal, , vol. 18, # 30 p. 9391 - 9396
