5-氯-2-甲氧基苯乙酮合成路线 （共 20 条）
参考文献
Journal of Organic Chemistry, , vol. 25, p. 1016 - 1020
参考文献
Bulletin de la Societe Chimique de France, , p. 3311 - 3318
参考文献
Chemische Berichte, , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, , vol. 446, p. 157 Anm. 2, 177
反应条件
copper(ll) bromide in chloroform; ethyl acetate 3 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 74 ;
WO 2005/019184 A1
反应条件
potassium permanganate
参考文献
Horton,W.J.; Robertson,D.E.
Journal of Organic Chemistry, 1960 , vol. 25, p. 1016 - 1020
反应条件
1: boron tribromide / dichloromethane / 1 h / -78 - 23 °C 2: 2 h / 100 °C 3: bromine / chloroform / 0.08 h / 0 - 23 °C View Scheme
参考文献
Bryan, Marian C.; Biswas, Kaustav; Peterkin, Tanya A.N.; Rzasa, Robert M.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 619 - 622
反应条件
(i) sulfur, Mor, (ii) NaOH, EtOH; Multistep reaction;
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
反应条件
boron tribromide in dichloromethane T=-78 - 23°C; 1 h;
参考文献
Bryan, Marian C.; Biswas, Kaustav; Peterkin, Tanya A.N.; Rzasa, Robert M.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 619 - 622
反应条件
1: acetic acid ester; sodium
2: concentrated hydriodic acid
View Scheme
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
反应条件
1: Br2 / diethyl ether / 20 °C
2: ethanol; H2O / 20 °C
View Scheme
参考文献
Lee, Sunkyung; Kim, Taemi; Lee, Byung Ho; Yoo, Sung-eun; Lee, Kyunghee; Yi, Kyu Yang
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1291 - 1295
