1,2,3,4-四氢喹啉-2-羧酸甲酯合成路线 （共 23 条）
反应条件
1.1: Irradiation 2.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 35 °C / Inert atmosphere 3.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 3.2: pH 8 / Saturated solution View Scheme
参考文献
Maj, Anna M.; Suisse, Isabelle; Meliet, Catherine; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4747 - 4750
反应条件
N-bromosuccinmide in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
WO2004/96210 A1, ;
Page/Page column 58 ;
反应条件
1.1: Irradiation 2.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 35 °C / Inert atmosphere 3.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 3.2: pH 8 / Saturated solution 4.1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine; (R)-Segphos® / isopropyl alcohol; toluene / 17 h / 20 °C / 22502.3 Torr / Autoclave View Scheme
参考文献
Maj, Anna M.; Suisse, Isabelle; Meliet, Catherine; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4747 - 4750
反应条件
1: LiAlH4 / tetrahydrofuran 2: I2, PPh3, imidazole / toluene; acetonitrile 3: dimethylformamide 4: 12N aq. HCl View Scheme
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
反应条件
α-chymotrypsine T=30°C; pH=7.4 - 7.5; 72 h; Resolution of racemateSoerensen-bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Kannenberg, Axel; Rost, Daniel; Eibauer, Stefan; Tiede, Sascha; Blechert, Siegfried
Angewandte Chemie - International Edition, 2011 , vol. 50, # 14 p. 3299 - 3302
反应条件
Pseudomonas cepacia lipase in tetrahydrofuran T=30°C; 30 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Alatorre-Santamaria, Sergio; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron Asymmetry, 2010 , vol. 21, # 18 p. 2307 - 2313
反应条件
Candida antarctica lipase B in tetrahydrofuran T=30°C; 30 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Alatorre-Santamaria, Sergio; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron Asymmetry, 2010 , vol. 21, # 18 p. 2307 - 2313
反应条件
1: Irradiation 2: (R)-(-)-5,5'-bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine / toluene / 17 h / 20 °C / 37503.8 Torr / Autoclave View Scheme
参考文献
Maj, Anna M.; Suisse, Isabelle; Meliet, Catherine; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4747 - 4750
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4747 - 4750
反应条件
1: Irradiation 2: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 35 °C / Inert atmosphere View Scheme
参考文献
Maj, Anna M.; Suisse, Isabelle; Meliet, Catherine; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4747 - 4750
