4-氨基-3-羟基苯甲酸甲酯合成路线 （共 30 条）
反应条件
hydrogenchloride T=0 - 20°C; 48 h;
参考文献
ALMIRALL, S.A.; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; PUIG DURAN, Carlos
Patent: WO2013/68554 A1, 2013 ;
Location in patent: Page/Page column 80 ;
反应条件
in methanol T=10 - 20°C; 48 h; Cooling with ice;
参考文献
Jonckers, Tim H.M.; Rouan, Marie-Claude; Hache, Geerwin; Schepens, Wim; Hallenberger, Sabine; Baumeister, Judith; Sasaki, Jennifer C.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 4998 - 5002
反应条件
hydrogen; palladium on activated charcoal in ethanol 6 h;
参考文献
Samih, Fouzia; Prudhomme, Michelle; Dauphin, Gerard; Jeminet, Georges
Tetrahedron, 1990 , vol. 46, # 15 p. 5177 - 5186
反应条件
1: 70 percent / conc. H2SO4 / Heating 2: 98 percent / H2 / Pd/C / ethanol / 6 h View Scheme
参考文献
Tetrahedron, , vol. 46, # 15 p. 5177 - 5186
参考文献
Heterocycles, , vol. 64, p. 193 - 198
反应条件
1: 73 percent / aq. NaHCO3 / ethyl acetate / 0.5 h / Ambient temperature 2: 77 percent / NaH / dimethylformamide / 60 °C View Scheme
参考文献
Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Tsutsui, Hisayoshi; Harada, Kengo; Ikeda, Shoji; Maruo, Joji; Morita, Tominori; Ohtaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1975 - 1983
反应条件
1: 86 percent / NaNO2; KI; HCl / 0 °C 2: 100 percent / NaH / 20 °C View Scheme
参考文献
Nguyen, Diem N.; Stump, Craig A.; Walsh, Eileen S.; Fernandes, Christine; Davide, Joseph P.; Ellis-Hutchings, Michelle; Robinson, Ronald G.; Williams, Theresa M.; Lobell, Robert B.; Huber, Hans E.; Buser, Carolyn A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1269 - 1273
反应条件
1.1: 90 percent / triethylamine / CH2Cl2 / 12 h / 20 °C 2.1: NaH / dimethylformamide / 0.5 h / 20 °C 2.2: 86 percent / dimethylformamide / 1 h 3.1: NaOH / methanol; tetrahydrofuran / 2 h / 60 °C View Scheme
参考文献
Ahn, Jung-Mo; Han, Sun-Young
Tetrahedron Letters, 2007 , vol. 48, # 20 p. 3543 - 3547
反应条件
in pyridine T=20°C; 36 h;
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 106-107 ;
