4-氨基-3-羟基苯甲酸甲酯合成路线 （共 30 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W.
Patent: WO2007/16525 A2, 2007 ;
Location in patent: Page/Page column 89 ;
WO 2007/016525 A2
反应条件
sodium hydroxide; toluene
参考文献
v. Meyer
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 265
反应条件
pyridine 12 h; Reflux;
参考文献
Jonckers, Tim H.M.; Rouan, Marie-Claude; Hache, Geerwin; Schepens, Wim; Hallenberger, Sabine; Baumeister, Judith; Sasaki, Jennifer C.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 4998 - 5002
反应条件
in tetrahydrofuran T=20°C;
参考文献
MERCK SHARP andamp; DOHME CORP.; HE, Jiafang; BAWIEC, John; LIU, Weiguo; LIANG, Gui-Bai; YANG, Lihu
Patent: WO2010/56717 A1, 2010 ;
Location in patent: Page/Page column 41; 42 ;
WO 2010/056717 A1
反应条件
in methanol 1.5 h; Reflux;
参考文献
Best, Daniel; Kujawa, Szymon; Lam, Hon Wai
Journal of the American Chemical Society, 2012 , vol. 134, # 44 p. 18193 - 18196
反应条件
1: With sodium nitrite in water T=0°C; 1 h; 2: With copper(I) bromide T=0 - 100°C; 1 h;
参考文献
Tularik Inc.
Patent: US2004/97485 A1, 2004 ;
Location in patent: Page/Page column 35 ;
US 20040097485 A1
反应条件
1: ethanol 2: methanol; sodium hydroxide View Scheme
参考文献
McElhinny Jr., Charles J.; Lewin, Anita H.; Mascarella, S. Wayne; Runyon, Scott; Brieaddy, Lawrence; Carroll, F. Ivy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6661 - 6664
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Kanebo, Ltd.
Patent: US5597820 A1, 1997 ;
反应条件
sodium hydrogencarbonate in ethyl acetate 0.5 h; Ambient temperature;
参考文献
Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Tsutsui, Hisayoshi; Harada, Kengo; Ikeda, Shoji; Maruo, Joji; Morita, Tominori; Ohtaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1975 - 1983
反应条件
1: With trifluoroacetic acid T=20°C; 1.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 108 ;
