4-氨基-3-羟基苯甲酸甲酯合成路线 （共 30 条）
反应条件
pyridinium p-toluenesulfonate; triethylamine in xylene 8.5 h; Heating / reflux;
参考文献
Eisai Co., Ltd.
Patent: EP1669348 A1, 2006 ;
Location in patent: Page/Page column 68 ;
参考文献
McElhinny Jr., Charles J.; Lewin, Anita H.; Mascarella, S. Wayne; Runyon, Scott; Brieaddy, Lawrence; Carroll, F. Ivy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6661 - 6664
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/82901 A1, 2005 ;
Location in patent: Page/Page column 33; 61 ;
参考文献
Perrey, David A.; Gilmour, Brian P.; Runyon, Scott P.; Thomas, Brian F.; Zhang, Yanan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2980 - 2985
反应条件
1: benzene 2: zinc chloride / 160 °C View Scheme
参考文献
v. Meyer
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 265
反应条件
hydrogenchloride; potassium iodide; sodium nitrite T=0°C;
参考文献
Nguyen, Diem N.; Stump, Craig A.; Walsh, Eileen S.; Fernandes, Christine; Davide, Joseph P.; Ellis-Hutchings, Michelle; Robinson, Ronald G.; Williams, Theresa M.; Lobell, Robert B.; Huber, Hans E.; Buser, Carolyn A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1269 - 1273
参考文献
Mohamed, Nadia A.; Sammour, Mohammad H.; Elshafai, Ali M.
Molecules, 2012 , vol. 17, # 12 p. 13969 - 13988
反应条件
1.1: HCl; NaNO2 / tetrahydrofuran / 0.33 h / 0 °C
1.2: 14 percent / KI / tetrahydrofuran / 0.75 h
2.1: 83 percent / Pd(Ph3P)4 / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
MacTough, Suzanne C.; Desolms, S. Jane; Shaw, Anthony W.; Abrams, Marc T.; Ciccarone, Terrence M.; Davide, Joseph P.; Hamilton, Kelly A.; Hutchinson, John H.; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Graham, Samuel L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1257 - 1260
参考文献
Best, Daniel; Kujawa, Szymon; Lam, Hon Wai
Journal of the American Chemical Society, 2012 , vol. 134, # 44 p. 18193 - 18196
反应条件
1.1: 90 percent / triethylamine / CH2Cl2 / 12 h / 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 83 percent / dimethylformamide / 1 h
3.1: trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Ahn, Jung-Mo; Han, Sun-Young
Tetrahedron Letters, 2007 , vol. 48, # 20 p. 3543 - 3547
