4-甲脒基吡啶水合盐酸盐合成路线 （共 31 条）
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; caesium carbonate in tert-butyl alcohol T=20°C; 0.0166667 h; Inert atmosphereSonication; 2: in tert-butyl alcohol T=85°C; 2 h; Inert atmosphere;
参考文献
McGowan, Meredeth A.; McAvoy, Camille Z.; Buchwald, Stephen L.
Organic Letters, 2012 , vol. 14, # 14 p. 3800 - 3803
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; caesium carbonate in tert-butyl alcohol T=20°C; 0.0166667 h; Inert atmosphereSonication; 2: in tert-butyl alcohol T=110°C; 2 h; Inert atmosphere;
参考文献
McGowan, Meredeth A.; McAvoy, Camille Z.; Buchwald, Stephen L.
Organic Letters, 2012 , vol. 14, # 14 p. 3800 - 3803
反应条件
sodium ethanolate in ethanol 6 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 128-129 ;
反应条件
1: KOEt / ethanol / Heating 2: DMF; SOCl2 / Heating 3: H2; i-Pr2NEt / Pd(OH)2/C / ethanol View Scheme
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
反应条件
sodium methylate; sulfur in methanol 6 h; Heating;
参考文献
Ishikawa, Tomoyasu; Matsunaga, Nobuyuki; Tawada, Hiroyuki; Kuroda, Noritaka; Nakayama, Yutaka; Ishibashi, Yukio; Tomimoto, Mitsumi; Ikeda, Yukihiro; Tagawa, Yoshihiko; Iizawa, Yuji; Okonogi, Kenji; Hashiguchi, Shohei; Miyake, Akio
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 11 p. 2427 - 2437
反应条件
1: 1.) NaH / 1.) THF, RT, 2 h, 2.) a) EtOH, RT, 24 h, b) reflux, 1 h 2: 90 percent / POCl3 / 1.5 h / Heating View Scheme
参考文献
Singh, Baldev; Lesher, George Y.
Heterocycles, 1990 , vol. 31, # 12 p. 2163 - 2172
反应条件
1: KOEt / ethanol / Heating
2: DMF; SOCl2 / Heating
3: H2; i-Pr2NEt / Pd(OH)2/C / ethanol
4: DIBAL-H / toluene; tetrahydrofuran
View Scheme
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
反应条件
1: 28.2 g / CH3ONa / methanol / 24 h / Heating
2: 100 percent / PhPOCl2 / 6 h / 150 - 170 °C
3: 97 percent / H2O; ethanol / 5 h / Heating
4: 57 percent / NaH / dimethylformamide / 2 h
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
sodium acetate in 1,4-dioxane
2 h; Heating;
参考文献
Lipinski, Christopher A.; Blizniak, Thaddeus E.; Craig, Rebecca H.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 566 - 570
反应条件
potassium ethanolate in ethanol
Heating;
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
