嘧啶-4,6-二甲酸二甲酯合成路线 （共 3 条）
反应条件
hydrogenchloride in water T=65°C; 3 h; Heating / reflux;
参考文献
Weithmann, Klaus-Ulrich; Habermann, Jorg; Kogler, Herbert; Kirsch, Reinhard; Wehner, Volkmar
Patent: US2003/229103 A1, 2003 ;
Location in patent: Page 9 ;
反应条件
sodium hydroxide in methanol T=20°C; 2 h;
参考文献
ISIS INNOVATION LIMITED; SCHOFIELD, Christopher, Joseph; MCDONOUGH, Michael; ROSE, Nathan; THALHAMMER, Armin
Patent: WO2010/43866 A2, 2010 ;
Location in patent: Page/Page column 77 ;
WO 2010/043866 A2
反应条件
1: ammonium hydroxide / 2 h / 35 °C / |Inert atmosphere; |Schlenk technique
2: N,N-dimethyl-formamide; trichlorophosphate / 12.5 h / |Inert atmosphere; |Schlenk technique
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参考文献
Fatila, Elisabeth M.; Clerac, Rodolphe; Rouzieres, Mathieu; Soldatov, Dmitriy V.; Jennings, Michael; Preuss, Kathryn E.
Journal of the American Chemical Society, 2013 , vol. 135, # 36 p. 13298 - 13301
